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RESEARCH ACCOMPLISHMENTS

Exercise Performance in Mice Depends on Circadian Rhythms
Scientists at TSRI have shown that the body’s circadian rhythms play a key role in exercise speed and endurance. The finding was published today in the journal Cell Metabolism. Research Associate Sabine D. Jordan (Lamia lab) was first author.

Firefly Gene Illuminates Ability of Optimized CRISPR-Cpf1 to Efficiently Edit Human Genome
TSRI scientists have improved a state-of-the-art gene-editing technology to advance the system’s ability to target, cut and paste genes within human and animal cells—and broadening the ways the CRISPR-Cpf1 editing system may be used to study and fight human diseases. Research Associate Guocai Zhong (Farzan lab) was first author.

Influenza Virus Can Overcome Potentially Crippling Mutations
In a new study, researchers demonstrated that in rare instances, influenza viruses handicapped by a single mutation can overcome their disadvantage with the aid of other mutations—a phenomenon known as epistasis. Research Associate Nicholas Wu (Lerner lab) was study first author.

Zika Reached Miami at Least Four Times, Caribbean Travel Likely Responsible
A new study by a large group of international researchers led by scientists at TSRI explains how Zika virus entered the United States via Florida in 2016—and how it might re-enter the country this year. TSRI Research Associate Nathan D. Grubaugh was lead author of the study.

Chemists Devise Simple Method for Making Sought-After Boronic Acid-Based Drugs and Other Products
Chemists at TSRI have developed a broad and strikingly easy method for synthesizing a class of molecules that have demonstrated value as pharmaceuticals. The co-lead authors of the paper, "Decarboxylative borylation," were Chao Li and Jie Wang, postdoctoral research associates in the Baran Laboratory.

Surprising Brain Change Appears to Drive Alcohol Dependence
A new study led by scientists at TSRI could help researchers develop personalized treatments for alcoholism and alcohol use disorder. TSRI Research Associate Florence Varodayan (Roberto lab) was study first author.

Professional Accomplishments

TSRI Postdoc Awarded ASPET Fellowship
Research Associate Jacques Nguyen, a member of the Taffe Lab, was selected for the American Society for Pharmacology and Experimental Therapeutics (ASPET) Washington Fellows program.

SoF Announces Fall Travel Award Winners
The Scripps California Society of Fellows (SoF) has announced the winners of this fall’s travel awards, which support the presentation of scholarly work at a scientific conference.

Robert Laprairie Ranks First in CIHR Fellowship Competition
Robert Laprairie, postdoctoral fellow in the Bohn lab, ranked first among more than 1,000 applicants for a competitive fellowship from the Canadian Institutes of Health Research (CIHR).

Anna Phan Wins Early-Career Fellowship
Anna Phan, a research associate in the Davis laboratory, has been awarded a two-year fellowship from the Canadian Institutes of Health Research. The competitive award provides recognition and funding for academic researchers early in their careers.

Jeffrey Rudolf Wins Beckman Fellowship
Jeffrey Rudolf, research associate in the Ben Shen lab, has won an Arnold O. Beckman Postdoctoral Fellowship.