Recent Advances in Stereoselective Chemistry
CHEM630
Course Directors: Ciaran Seath and Masayuki Wasa
Term: Winter
Credits: 3.0
COURSE DESCRIPTION
This course provides an in-depth exploration of the principles and methodologies underpinning enantio- and diastereo-selective synthesis. We will begin with a concise review of the fundamental concepts in stereoselective synthesis and physical organic chemistry, focusing on mechanistic models essential for understanding and predicting stereochemical outcomes, as well as the thermodynamic and kinetic factors that influence reaction pathways. Emphasis will be placed on the role of chemical catalysis in achieving high levels of selectivity.
Throughout the course, students will examine a series of seminal examples, including chiral auxiliary chemistry and enantioselective processes facilitated by stoichiometric Lewis acids and bases. However, the primary focus will be on transformations enabled by enantiopure catalysts. The course will also critically evaluate the current state-of-the-art methods in stereoselective synthesis, addressing the fundamental limitations and remaining challenges in the field. Through lectures, case studies, and problem-solving sessions, students will gain a comprehensive understanding of both the theoretical and practical aspects of stereoselective synthesis, preparing them for advanced research and applications in modern organic chemistry.
