Structural Biology and Biophysics II - STBIO511

Focuses on biophysical methods used to study structure and function

Course Directors: Gabriel Lander, Andrew Ward, and Ian Wilson
Term: Winter
Credits: 3.0

This course focuses on the current state-of-the-art biophysical methods that are being applied to study the structure and function of biological macromolecules and biological systems at the atomic level. Topics covered include mass spectrometry, proteomics, chemical biology approaches, single molecule techniques, spectrosocopy, molecular dynamics and modeling. There is also a focus on post-translational modifications and their impact on protein structure and function. Finally, we will discuss the use of combinations of methods, so called hybrid methods, including the combined use of computational tools with experimental data, to further structural elucidation of challenging macromolecular complexes and biological systems. In each section of the course, the theoretical underpinnings and the practical applications are covered. Each technique section will contain journal club, in which the students will present and discuss current research articles in class in the presence of experts in the field. The course is designed to provide a basic familiarity with the most common techniques used in biophysics and their applications to challenging problems in biology.

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