Drug Discovery and Development - TRBIO450

Reviews the processes through which potential new therapeutics are identified

Course Directors: Louis Scampavia and Tim Spicer
Term: Winter (every other year)
Credits: 3.0

The course reviews the processes through which potential new therapeutics are identified. This includes the description of the roles played by a wide range of scientific disciplines, including biology, chemistry, in vitro/in vivo pharmacology, drug metabolism, pharmacokinetics and ADME/Tox in the early drug discovery process. The complexity of discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication will be reviewed. A historical perspective is considered by reviewing classical pharmacology/phenotypic and drug discovery or the idea that the effect of a drug in the human body is mediated by specific interactions of the drug molecule with biological macromolecules. Landmark drugs will be discussed.

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